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Obesity , 2025, 33.9: 1657-1667

The mechanistic rationale for the combination rests on the complementary and additive nature of GHRH receptor and ghrelin receptor activation with research demonstrating that simultaneous engagement of both receptor pathways produces greater GH release than either compound alone, while Ipamorelins selectivity profile minimizes cortisol and prolactin co-secretion that can confound GH axis research outcomes

However, gastrointestinal side effects (nausea, constipation, diarrhea) still occur, typically mild to moderate in severity

[13] A further complication of severe deficiency is the neurological complex known as subacute combined degeneration of spinal cord